Table 3.
Effects of the subchronic oral administration of MEFL on biochemical parameters in SD rats.
| a Treatment | |||||
| Control | MEFL (mg/kg) | ||||
| 0 mg/kg | 750 | 1250 | 2500 | ||
| Male rats | |||||
| Total Protein | g/l | 74.50±1.88 | 76.33±1.09 | 68.66±2.6 | 69.6±1.82 |
| Albumin | g/l | 31.75±1.58 | 33.33±0.95 | 33.33±0.95 | 32.33±1.58 |
| Globulin | g/l | 38.17±0.87 | 36.00±0.63 | 35.67±1.02 | 36.33±1.50 |
| Albumin/Globulin Ratio | 0.75±0.05 | 0.93±0.03 | 0.93±0.03 | 0.84±0.05 | |
| Total Bilirubin | μmol/l | <2 | <2 | <3 | <2 |
| Alkaline Phosphatase | U/l | 406.25±58.74 | 382.50±83.11 | 334.83±68.08 | 351.0±69.54 |
| Alanine Aminotransferase | U/l | 62.50±10.37 | 77.00±12.56 | 71.66±17.42 | 69.80±14.88 |
| Aspartate Aminotransferase | U/l | 248.00±10.42 | 241.50±12.45 | 239.50±8.45 | 252.40±9.82 |
| Gamma Glutamyl Transferase | U/l | <3 | <3 | <3 | <3 |
| Urea | mmol/l | 6.07±0.35 | 6.18±0.83*) | 7.12±0.27*) | 7.50±0.39**) |
| Potassium | mmol/l | 6.30± 0.06 | 5.08±0.05 | 5.90±0.03 | 6.26±0.02 |
| Sodium | mmol/l | 141.50±0.31 | 139.17±0.40 | 139.5±0.40 | 140.80±0.48 |
| Chloride | mmol/l | 98.75±5.49 | 100.83 ±4.31 | 101.00±6.63 | 101.25± 2.10 |
| Creatinine | μmol/l | 30.50±1.72 | 30.00±1.99 | 31.16± 1.16 | 26.20±1.27 |
| Uric Acid | μmol/l | 0.17±0.02 | 0.16±18.35 | 0.14±0.05 | 0.13±0.04 |
| Female rats | |||||
| Total Protein | g/l | 78.50±1.23 | 77.83±1.66 | 76.20±2.48 | 71.23±2.89 |
| Albumin | g/l | 33.83±0.98 | 35.00±0.68 | 34.00±1.39 | 33.17±0.60 |
| Globulin | g/l | 47.66±0.79 | 44.20±2.94 | 44.20±2.94 | 43.2±1.12 |
| Albumin/Globulin Ratio | 0.65±0.10 | 0.77±0.03 | 0.74±0.02 | 0.64±0.05 | |
| Total Bilirubin | μmol/l | <2 | <2 | <2 | <2 |
| Alkaline Phosphatase | IU/l | 334.33±5.05 | 415.83±4.44 | 339.80±11.50 | 416.8±21.25 |
| Alanine Aminotransferase | U/L | 102.33±2.67 | 118.50±3.29 | 101.83±4.45 | 111.33±2.17 |
| Aspartate Aminotransferase | U/L | 266.33± 13.94 | 266.83±4.09 | 267.17±14.86 | 270.6±15.19 |
| Gamma Glutamyl Transferase | U/L | <3 | <3 | <3 | <3 |
| Urea | mmol/l | 7.16±0.35 | 8.30±0.26*) | 10.30±0.28**) | 7.16±0.17 |
| Potassium | mmol/l | 4.48±0.10 | 4.42±0.07 | 4.57±0.08 | 4.33±0.11 |
| Sodium | mmol/l | 138.83±1.72 | 143.33±0.95 | 136.33±1.00 | 134.83±1.65 |
| Chloride | mmol/l | 101.83±1.45 | 99.60±1.67 | 100.00±0.52 | 98.00±1.06 |
| Creatinine | μmol/l | 29.50±2.24 | 26.33±1.50 | 27.20±2.68 | 23.20±2.38 |
| Uric Acid | μmol/l | 0.20±0.05 | 0.20±54.09 | 0.19±0.05 | 0.20±0.09 |
Values are the mean ±S.E.M., n = 6.
*
p<0.05,
**
p<0.01.