FIGURE 10.

Modulation of hemichannel activity. (A) Schematic of the experiment. (B) SpIH current recordings from a HeLaCx43/SpIH cell perfused with Ca²⁺-free KAsp external solution containing 200 μM carbenoxolone. No SpIH current increase was detected during local application of cAMP (red current traces) in five cell preparations (6.8 ± 2.2 and 6.6 ± 2.8 pA/pF, before and during local application of cAMP, respectively; P = 1.0). (C) SpIH current recorded from connexin deficient HeLa parental cells transfected with SpIH during local application of cAMP (red current traces; 6.8 ± 1.9 and 8.7 ± 2.8 pA/pF, before and during local application of cAMP, respectively; n = 10, P = 0.734.