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Model for acquired Fd resistance mechanism. MCL-1 degradation following Fd treatment released BIM and BECN1, leading to apoptosis and cell death-associated autophagy in Fd-sensitive cells. In FdR cells there was low-BIM expression and BECN1 was inhibited by high MCL-1/BECN1 interaction. FdR cells have a higher metabolic demand, which activates AMPK-dependent autophagy and promotes survival in these cells
