Figure 5.

Combination of SRT2183 with panobinostat induces greater phosphorylation of H2A.X and acetylation of H4 in ALL cell lines. (a) Reh cells and (b) NALM-6 cells were treated for 24 h with the indicated concentrations of SRT2183, panobinostat, or a combination of these drugs. Following this, western blot analysis of phospho-H2A.X and acetyl-H4 proteins was performed on the lysates from those cells. The levels of β-actin protein served as loading controls. Results are representative of three independent experiments