Figure 1.

Increased mortality in TLR4^−/− mice exposed to IR. (a) Survival to day 360 of TLR4^+/− mice and TLR4^−/− mice without IR in SPF conditions (N=6). (b) TLR4^+/− control (N=30) and TLR4^−/− (N=18) mice ((TLR4^+/− control (N=10) and TLR4^−/− (N=6) in each group)) were each randomly divided into three groups and exposed to 5, 7 or 9 Gy ⁶⁰Co-γ radiation (dose rate: 1 Gy/min). Survival was monitored until day 30 after IR. (c) Linear regression analysis of the survival rate for TLR4^−/− mice and TLR4^+/− control mice after IR. The equation and the correlation coefficient for the line are given. The calculated DRF using these equations was 1.5 (TLR4^+/− mice versus TLR4^−/− mice). Blue circles: TLR4^+/− mice and red squares: TLR4^−/− mice; *P<0.05.