Figure 8.

Radiation leads to significant endotoxemia in a commensal dependent manner. (a) Normal C57BL/10 mice were exposed to 5 Gy and the level of LPS in serum was measured 0, 24, 48, 96 and 144 h after IR. (b) Normal C57BL/10 mice were subjected to 0, 3, 5, 7 and 9 Gy and the level of LPS in serum was measured 48 h after IR. (c) Age and sex matched TLR4^+/− and TLR4^−/− mice were treated with or without 5 Gy and the level of LPS in serum was detected 48 h after IR. (d) Age and sex matched commensal normal or gut flora-depleted animals were treated with or without 5 Gy and the level of LPS in serum was measured 48 h after IR. Cipro and PMB groups were two models of commensal-depleted animals (Methods section). *P<0.05; NS: No significant difference detected