Table 1. Genes significantly upregulated in glomeruli by both strain and sex.
|
Fold change compared with B6 female |
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|---|---|---|---|---|---|---|---|---|---|
| Probe set | Gene symbol | Gene title | Mouse chromosomal location (chromosome (Chr):Mb) | Human chromosomal location (Chr:Mb) | B6 male | FVB/N female | FVB/N male | P-value (sex) | P-value (strain) |
| 1450947_at | 2610528J11Rik | RIKEN cDNA 2610528J11 gene | 4:118.5 | 1:43.7 | 2.5 | 2.0 | 6.8 | 0.017 | 0.012 |
| 1431904_at | 4933427G17Rik | RIKEN cDNA 4933427G17 gene | 7:121.0 | NA | 4.8 | 2.8 | 8.0 | 0.024 | 0.045 |
| 1423523_at | Aass | Aminoadipate-semialdehyde synthase | 6:23.1 | 7:121.7 | 3.0 | 1.6 | 6.8 | 0.013 | 0.043 |
| 1448539_a_at | Acy3 | Aspartoacylase (aminoacylase) 3 | 19:4.0 | 11:67.4 | 4.8 | 1.7 | 12.8 | 0.001 | 0.009 |
| 1424400_a_at | Aldh1l1 | Aldehyde dehydrogenase 1 family, member L1 | 6:90.5 | 3:125.8 | 2.7 | 2.0 | 6.1 | 0.041 | 0.042 |
| 1416203_at | Aqp1 | Aquaporin 1 | 6:55.3 | 7:30.9 | 2.1 | 2.6 | 6.8 | 0.032 | 0.003 |
| 1418914_s_at | Bhmt2 | Betaine-homocysteine methyltransferase 2 | 13:93.7 | 5:78.4 | 2.9 | 2.0 | 9.3 | 0.045 | 0.037 |
| 1451625_a_at | C8g | Complement component 8, γ polypeptide | 2:25.5 | 9:139.8 | 2.7 | 2.5 | 9.5 | 0.020 | 0.006 |
| 1418976_s_at | Cideb | Cell death-inducing DNA fragmentation factor, α subunit-like effector B | 14:55.8 | 14:24.8 | 2.2 | 1.6 | 6.8 | 0.013 | 0.012 |
| 1424811_at | Cml5 | Camello-like 5 | 6:85.8 | 2:73.9 | 10.8 | 6.4 | 65.7 | 0.030 | 0.019 |
| 1423701_at | Coasy | Coenzyme A synthase | 11:101.1 | 17:40.7 | 2.1 | 1.7 | 6.5 | 0.037 | 0.029 |
| 1424352_at | Cyp4a12a | Cytochrome P450, family 4, subfamily a, polypeptide 12a | 4:115.3 | 1:47.4 | 28.6 | 2.2 | 359.8 | 0.003 | 0.022 |
| 1428738_a_at | D14Ertd449e/// ENSMUSG00000072676 | DNA segment, Chr 14, ERATO Doi 449, expressed/// predicted gene, ENSMUSG00000072676 | 14:26.1 | 10:81.8 | 1.6 | 1.6 | 6.8 | 0.035 | 0.013 |
| 1417393_a_at | Fam132a | Family with sequence similarity 132, member A (also known as C1qdc2) | 4:156.0 | 1:1.2 | 1.5 | 1.6 | 3.4 | 0.023 | 0.005 |
| 1417422_at | Gnmt | Glycine N-methyltransferase | 17:46.8 | 6:42.9 | 3.0 | 2.3 | 8.9 | 0.037 | 0.024 |
| 1420712_a_at | Hpn | Hepsin | 7:31.1 | 19:35.5 | 2.0 | 1.6 | 6.4 | 0.033 | 0.025 |
| 1460232_s_at | Hsd3b2/// Hsd3b3/// Hsd3b6 | Hydroxy-δ-5-steroid dehydrogenase, 3 β- and steroid δ-isomerase 2/// hydroxy-δ-5-steroid dehydrogenase, 3 β- and steroid δ-isomerase 3/// hydroxy-δ-5-steroid dehydrogenase, 3 beta- and steroid δ-isomerase 6 | 3:98.7 | 1:120.0 | 4.4 | 4.5 | 11.5 | 0.025 | 0.005 |
| 1428614_at | Ldhd | Lactate dehydrogenase D | 8:111.6 | 16:75.1 | 5.0 | 1.8 | 15.4 | 0.002 | 0.008 |
| 1419504_at | LOC100047046/// Mogat1 | Similar to monoacylglycerol O-acyltransferase 1/// monoacylglycerol O-acyltransferase 1 | 1:78.5 | 2:223.5 | 8.3 | 6.0 | 69.4 | 0.005 | 0.002 |
| 1419520_at | Nat8 | N-acetyltransferase 8 | 6:85.8 | 2:73.9 | 3.2 | 2.6 | 23.3 | 0.008 | 0.003 |
| 1455490_at | Pigr | Polymeric immunoglobin receptor, | 1:130.8 | 1:207.1 | 3.9 | 2.4 | 25.5 | 0.004 | 0.003 |
| 1419117_at | Slc22a2 | Solute carrier family 22 (organic cation transporter), member 2 | 17:12.6 | 6:160.6 | 2.5 | 1.8 | 9.0 | 0.029 | 0.023 |
| 1417072_at | Slc22a6 | Solute carrier family 22 (organic anion transporter), member 6 | 19:8.6 | 11:62.7 | 3.7 | 1.7 | 16.8 | 0.020 | 0.046 |
| 1425606_at | Slc5a8 | Solute carrier family 5 (iodide transporter), member 8 | 10:88.9 | 12:101.5 | 3.8 | 1.5 | 15.3 | 0.008 | 0.027 |
| 1436667_at | Slc6a20b | Solute carrier family 6, member 20b | 9:123.6 | 3:45.8 | 2.1 | 2.1 | 6.5 | 0.036 | 0.009 |
| 1449301_at | Slc7a13 | Solute carrier family 7, (cationic amino acid transporter, y+ system) member 13 | 4:19.8 | 8:87.2 | 224.0 | 3.9 | 1267.6 | <0.001 | 0.005 |
| 1420379_at | Slco1a1 | Solute carrier organic anion transporter family, member 1a1 | 6:141.9 | 12:21.4 | 36.0 | 3.4 | 567.4 | <0.001 | 0.002 |
| 1449409_at | Sult1c2 | Sulfotransferase family, cytosolic, 1C, member 2 | 17:53.8 | 2:108.9 | 1.5 | 2.5 | 5.9 | 0.036 | 0.001 |
| 1451528_at | Tmem82 | Transmembrane protein 82 | 4:141.6 | 1:16.1 | 1.7 | 1.7 | 6.7 | 0.036 | 0.009 |
| 1430889_a_at | Tpmt | Thiopurine methyltransferase | 13:47.0 | 6:18.1 | 2.1 | 1.8 | 13.7 | 0.020 | 0.007 |
| 1449430_a_at | Treh | Trehalase (brush-border membrane glycoprotein) | 9:44.7 | 11:118.5 | 3.4 | 3.6 | 41.9 | 0.008 | 0.001 |
| 1448609_at | Tst | Thiosulfate sulfurtransferase, mitochondrial | 15:78.4 | 22:37.4 | 2.2 | 2.1 | 7.3 | 0.015 | 0.004 |
| 1451373_at | Ugt3a1 | UDP glycosyltransferases 3 family, polypeptide A1 | 15:9.3 | 5:36.0 | 3.1 | 1.9 | 13.7 | 0.028 | 0.022 |
| 1460244_at | Upb1 | Ureidopropionase, β | 10:75.4 | 22:24.9 | 1.8 | 1.6 | 5.2 | 0.048 | 0.030 |
All genes were significantly altered by both strain and gender (P<0.05), followed the direction of albuminuria in the four groups assessed, and varied by >1.5-fold in individual comparisons between different sexes in both B6 and FVB/N mice and between mice of the same sex but from different strains. Fold changes are presented relative to B6 female mice (given a value of 1) that had the lowest albumin excretion rate. NA, not available.