Table 2. Genes significantly downregulated in glomeruli by both strain and sex.
|
Fold change compared with B6 female |
|||||||||
|---|---|---|---|---|---|---|---|---|---|
| Probe set | Gene symbol | Gene title | Mouse chromosomal location | Human chromosomal location | B6 male | FVB/N female | FVB/N male | P-value (sex) | P-value (strain) |
| 1445938_at | 5930427L02Rik | RIKEN cDNA 5930427L02 gene | NA | NA | −1.9 | −1.5 | −29.4 | 0.049 | 0.017 |
| 1416003_at | Cldn11 | Claudin 11 | 3:31.1 | 3:170.1 | −2.6 | −2.2 | −15.5 | 0.036 | 0.009 |
| 1450952_at | Pln | Phospholamban | 10:53.3 | 6:118.9 | −1.5 | −1.6 | −4.7 | 0.010 | 0.002 |
| 1425546_a_at | Trf | Transferrin | 9:103.2 | 3:133.5 | −1.8 | −1.5 | −3.4 | 0.046 | 0.042 |
| 1446477_at | Zfp622 | Zinc-finger protein 622 | 15:26.0 | 5:16.5 | −2.0 | −2.1 | −3.4 | 0.023 | 0.004 |
All genes were significantly altered by both strain and gender (P<0.05), followed the direction of albuminuria in the four groups assessed, and varied by >1.5-fold in individual comparisons between different sexes in both B6 and FVB/N mice and between mice of the same sex but from different strains. Fold changes are presented relative to B6 female mice (given a value of 1) that had the lowest albumin excretion rate. NA, not available.