Table 3.

Univariate and multivariate analysis of factors associated with use of non-guideline based care, vancomycin and granulocyte colony stimulating factors.

	Vancomycin				Granulocyte colony stimulating factor
	N	(%)¹	Univariate OR	Multivariate OR	N	(%)¹	Univariate OR	Multivariate OR
	9311	(36.9)			15,880	(62.9)
Age
<60 years	4484	(40.0)	Referent	Referent	6775	(60.5)	Referent	Referent
≥60 years	4827	(34.4)	0.77 (0.72–0.84)^*	0.77 (0.71–0.84)^*	9105	(64.9)	1.22 (1.15–1.28)^*	1.10 (1.01–1.20)^*
Gender
Male	3824	(38.3)	Referent	Referent	6442	(64.6)	Referent	Referent
Female	5487	(36.0)	0.90 (0.86–0.95)^*	1.00 (0.93–1.09)	9438	(61.9)	0.89 (0.84–0.94)^*	1.03 (0.94–1.12)
Year of diagnosis
2000–2003	1691	(22.8)	Referent	Referent	5261	(71.0)	Referent	Referent
2004–2006	2526	(34.3)	1.56 (1.44–1.70)^*	1.73 (1.58–1.89)^*	4613	(62.7)	0.69 (0.64–0.74)^*	0.58 (0.53–0.63)^*
2007–2010	5094	(48.7)	2.97 (2.73–3.22)^*	3.40 (3.11–3.71)^*	6006	(57.4)	0.55 (0.52–0.59)^*	0.42 (0.38–0.46)^*
Race
White	6705	(36.6)	Referent	Referent	11,257	(61.5)	Referent	Referent
Black	1064	(44.7)	1.12 (1.01–1.25)^*	1.21 (1.08–1.35)^*	1524	(64.1)	1.12 (1.02–1.22)^*	1.17 (1.04–1.32)^*
Other	1542	(34.0)	0.94 (0.85–1.03)	0.92 (0.84–1.01)	3099	(68.4)	1.36 (1.27–1.45)^*	1.22 (1.10–1.35)^*
Marital status
Married	5198	(36.6)	Referent	Referent	8983	(63.2)	Referent	Referent
Single	1592	(43.6)	1.06 (0.97–1.16)	1.10 (1.00–1.22)^*	2275	(62.3)	0.96 (0.89–1.04)	1.03 (0.93–1.14)
Unknown	2521	(34.2)	0.98 (0.91–1.06)	0.96 (0.89–1.04)	4622	(62.8)	0.98 (0.93–1.04)	0.96 (0.88–1.04)
Insurance status
Medicare	3761	(34.4)	Referent	Referent	7048	(65.3)	Referent	Referent
Medicaid	818	(38.4)	0.96 (0.85–1.09)	0.94 (0.83–1.08)	1341	(62.9)	0.90 (0.82–0.99)^*	1.05 (0.91–1.20)
Commercial	4275	(38.5)	1.04 (0.96–1.12)	1.05 (0.97–1.15)	6729	(60.7)	0.82 (0.78–0.87)^*	0.93 (0.85–1.01)
Uninsured	219	(37.6)	0.87 (0.70–1.06)	0.84 (0.67–1.05)	384	(65.9)	1.03 (0.86–1.22)	1.04 (0.82–1.31)
Unknown	238	(38.0)	1.09 (0.90–1.33)	1.07 (0.86–1.32)	378	(60.4)	0.81 (0.69–0.96)^*	0.87 (0.70–1.09)
Location
Metropolitan	8319	(37.9)	Referent	Referent	13,815	(63.0)	Referent	Referent
Non-metropolitan	992	(30.0)	0.75 (0.61–0.92)^*	0.71 (0.62–0.81)	2065	(62.4)	0.98 (0.90–1.05)	0.90 (0.77–1.06)
Teaching status
Non-teaching	4828	(34.3)	Referent	Referent	9212	(65.4)	Referent	Referent
Teaching	4483	(40.2)	1.16 (0.96–1.39)	1.10 (0.99–1.22)	6668	(59.8)	0.79 (0.75–0.83)^*	0.71 (0.63–0.80)^*
Hospital size
<400 beds	3867	(33.7)	Referent	Referent	7308	(63.7)	Referent	Referent
400–600 beds	2560	(34.7)	1.06 (0.87–1.29)	0.97 (0.87–1.09)	4871	(66.1)	1.11 (1.05–1.18)^*	1.22 (1.07–1.40)^*
>600 beds	2884	(45.2)	1.34 (1.01–1.78)^*	1.30 (1.13–1.50)^*	3701	(58.0)	0.79 (0.74–0.84)^*	0.80 (0.67–0.95)^*
Hospital location
Eastern	1344	(41.2)	Referent	Referent	2073	(63.5)	Referent	Referent
Midwest	2020	(40.2)	1.09 (0.85–1.40)	1.06 (0.92–1.22)	3055	(60.7)	0.89 (0.81–0.97)^*	0.72 (0.61–0.86)^*
Southern	4765	(35.4)	1.03 (0.81–1.31)	0.97 (0.85–1.11)	8396	(62.3)	0.95 (0.88–1.03)	0.96 (0.82–1.12)
West	1182	(34.2)	0.89 (0.67–1.18)	0.84 (0.71–0.99)^*	2356	(68.1)	1.23 (1.11–1.36)^*	1.10 (0.91–1.34)
Comorbidity
<2	1162	(34.8)	Referent	Referent	2058	(61.5)	Referent	Referent
2	1468	(35.6)	0.99 (0.89–1.11)	0.98 (0.88–1.10)	2505	(60.7)	0.97 (0.88–1.06)	0.95 (0.85–1.08)
>2	6681	(37.6)	1.13 (1.03–1.23)^*	1.12 (1.02–1.24)^*	11,317	(63.7)	1.10 (1.02–1.18)^*	1.04 (0.94–1.16)
Physician specialty
Medical oncology	5674	(35.4)	Referent	Referent	9899	(61.7)	Referent	Referent
Internal medicine	2163	(43.7)	1.28 (1.16–1.41)^*	1.38 (1.23–1.54)^*	3306	(66.8)	1.25 (1.17–1.33)^*	1.23 (1.08–1.40)^*
Family practice	498	(34.9)	0.94 (0.81–1.09)	0.93 (0.79–1.10)	870	(61.0)	0.97 (0.87–1.08)	0.97 (0.80–1.16)
Hospitalist	438	(50.7)	1.62 (1.36–1.93)^*	1.61 (1.32–1.96)^*	533	(61.7)	1.00 (0.87–1.45)	0.99 (0.79–1.25)
Other	381	(31.8)	0.78 (0.67–0.92)^*	0.75 (0.62–0.91)^*	757	(63.2)	1.07 (0.94–1.20)	1.03 (0.83–1.28)
Unknown	157	(20.7)	1.03 (0.79–1.35)	1.10 (0.80–1.52)	515	(68.0)	1.32 (1.13–1.54)^*	0.68 (0.47–0.98)^*
Physician volume
Low	3343	(40.2)	Referent	Referent	5350	(64.3)	Referent	Referent
Intermediate	3107	(36.6)	0.99 (0.91–1.07)	0.94 (0.85–1.04)	5407	(63.8)	0.98 (0.92–1.04)	1.02 (0.90–1.15)
High	2861	(33.9)	0.88 (0.80–0.97)^*	0.77 (0.67–0.88)^*	5123	(60.7)	0.86 (0.80–0.91)^*	0.88 (0.74–1.04)
Hospital volume
Low	2742	(32.8)	Referent	Referent	5492	(65.7)	Referent	Referent
Intermediate	2979	(35.8)	1.03 (0.85–1.24)	1.25 (1.12–1.39)^*	5276	(63.4)	0.91 (0.85–0.97)^*	0.95 (0.83–1.08)
High	3590	(42.0)	1.21 (0.92–1.57)	1.45 (1.27–1.65)^*	5112	(59.8)	0.78 (0.73–0.83)^*	1.04 (0.89–1.23)
Primary tumor site
Colorectal	793	(37.0)	1.17 (0.92–1.48)	1.21 (0.94–1.56)	1476	(68.9)	1.34 (1.22–1.47)^*	1.29 (0.98–1.70)
Other gastrointestinal	743	(38.7)	1.24 (0.98–1.58)	1.31 (1.01–1.69)^*	1257	(65.5)	1.13 (1.02–1.24)^*	1.18 (0.89–1.56)
Head and neck	475	(42.3)	1.38 (1.08–1.77)^*	1.42 (1.09–1.86)^*	753	(67.1)	1.21 (1.07–1.38)^*	1.24 (0.92–1.65)
Lung	1998	(32.1)	0.90 (0.72–1.13)^*	0.91 (0.72–1.17)	4069	(65.3)	1.14 (1.08–1.21)^*	1.05 (0.81–1.36)
Breast	2331	(34.8)	1.15 (0.91–1.45)^*	1.17 (0.92–1.50)	3922	(58.6)	0.78 (0.74–0.82)^*	0.74 (0.56–0.96)^*
Skin	98	(46.0)	1.68 (1.18–2.40)^*	1.85 (1.26–2.72)^*	141	(66.2)	1.15 (0.87–1.54)	1.02 (0.66–1.56)
Soft tissue	455	(45.0)	1.49 (1.15–1.92)^*	1.66 (1.25–2.19)^*	519	(51.3)	0.61 (0.54–0.69)^*	0.64 (0.47–0.86)^*
Genitourinary	523	(36.6)	1.08 (0.86–1.39)	1.13 (0.87–1.46)	948	(66.3)	1.17 (1.05–1.31)^*	1.10 (0.83–1.46)
Gynecologic	478	(32.8)	0.99 (0.77–1.28)	1.11 (0.84–1.46)	967	(66.3)	1.17 (1.05–1.31)^*	1.10 (0.82–1.48)
Lymphoma	1445	(47.1)	1.76 (1.39–2.22)^*	1.85 (1.44–2.39)^*	1856	(60.5)	0.89 (0.82–0.96)^*	0.85 (0.65–1.12)
Brain	100	(43.9)	1.46 (1.02–2.10)^*	1.40 (0.93–2.09)	158	(69.3)	1.33 (1.00–1.77)^*	1.57 (1.00–2.46)^*
Disease characteristics
Sepsis	1668	(54.0)	1.80 (1.64–1.97)^*	1.86 (1.69–2.05)^*	2006	(65.0)	1.11 (1.02–1.20)^*	1.02 (0.92–1.14)
Pneumonia	998	(48.9)	1.61 (1.44–1.79)^*	1.65 (1.47–1.85)^*	1371	(67.2)	1.23 (1.11–1.35)^*	1.24 (1.09–1.40)^*
Intensive care use	1059	(65.1)	2.38 (2.09–2.71)^*	2.63 (2.29–3.03)^*	1171	(72.0)	1.55 (1.39–1.74)^*	1.64 (1.40–1.92)^*
Hypotension	38	(40.4)	0.89 (0.56–1.42)	0.98 (0.59–1.6)	66	(70.2)	1.39 (0.89–2.16)	1.41 (0.81–2.47)
Mechanical ventilation	271	(69.7)	1.78 (1.37–2.31)^*	1.81 (1.37–2.40)^*	276	(71.0)	1.45 (1.16–1.80)^*	1.04 (0.77–1.41)

Reflects the percentage of patients who received guideline-concordant care.

p<0.05