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. Author manuscript; available in PMC: 2013 Aug 15.
Published in final edited form as: Cancer. 2012 Feb 22;118(16):3993–4003. doi: 10.1002/cncr.26656

Figure 1. Response of NSCLC cell lines carrying mut EGFR to treatment with PQIP.

Figure 1

(A) The IGF-1R signaling pathway is activated by IGF-1 in mut EGFR cells. (B) PQIP inhibits IGF-1R phosphorylation, shown in a subset of mut EGFR cell lines. (C) PQIP does not affect cell viability or anchorage-independent colony formation, shown in 3 mut EGFR cell lines. Columns, means of 3 independent experiments; bars, standard deviation.