Table 2. Quantitation of sources of reactive oxygen and nitrogen species and inflammation in choroid plexus.
The means (±standard deviation) indicate either the density of immunoreactive cells per mm2 of choroid plexus tissue (NOX1, p22phox, MPO, iNOS, CD68 and CD3) or densitometric values of immunoreactivity (HLA and CD163), when threshold was kept constant between cases. Parentheses indicate the number of cases studied and p values in left hand column were derived from Kruskal-Wallis test. P values in remaining columns were when compared with controls using Mann-Whitney U-test.
| MS | PD | AD | CON | |
|---|---|---|---|---|
| NOX1 (p<0.001) |
257.59 ± 114.77 (n=5) (p=0.001) |
94.35 ± 36.73 (n=3) |
164.30 ± 43.84 (n=2) (p=0.057) |
95.54 ± 44.81 (n=5) |
| p22phox (p=0.069) |
34.45 ± 16.53 (n=5) |
26.35 ± 14.72 (n=3) |
21.33 ± 8.17 (n=3) |
20.53 ± 7.78 (n=5) |
| MPO (p=0.004) |
40.64 ± 37.12 (n=5) (p=0.004) |
10.55 ± 7.09 (n=3) |
6.87 ± 6.87 (n=2) |
9.16 ± 7.19 (n=5) |
| iNOS (p<0.001) |
22.23 ± 6.44 (n=5) (p<0.001) |
13.83 ± 2.58 (n=3) |
12.43 ± 3.76 (n=3) |
11.29 ± 5.29 (n=5) |
| CD68 (p=0.004) |
64.81 ± 48.31 (n=5) (p=0.036) |
32.60 ± 6.99 (n=3) |
17.02 ± 14.76 (n=3) (p=0.017) |
34.09 ± 12.57 (n=5) |
| HLA (p<0.001) |
17.51 ± 5.96 (n=5) (p=0.009) |
13.28 ± 3.19 (n=3) |
5.64 ± 3.81 (n=3) |
10.49 ± 2.08 (n=6) |
| CD163 (p=0.245) |
7.22 ± 3.55 (n=5) |
7.23 ± 2.01 (n=3) |
5.60 ± 2.64 (n=3) |
5.36 ± 1.87 (n=5) |
| CD3 (p=0.129) |
51.65 ±19.87 (n=6) |
21.92 ±5.18 (n=3) |
24.46 ± 17.53 (n=3) |
45.58 ± 22.24 (n=5) |