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. 2013 Jun 6;3:1949. doi: 10.1038/srep01949

Figure 6. GC reduces systemic exposure to doxorubicin, while elevating intracellular tumour accumulation.

Figure 6

(A) Semi-logarithmic doxorubicin plasma concentration-time curve after i.v. injection of LDox GC, LDox and fDox. Plasma levels (μM) were expressed per injected dose (mean, SEM, n = 3). (B) Intracellular and total tissue doxorubicin in the tumour and the heart. Data are expressed as the AUC per gram tissue, per gram injected doxorubicin. GC elevates intracellular drug accumulation in the tumour by a factor two (p < 0.05). (Mean, SEM, n = 12).