Figure 5.

Responses of mice in trials when the test gas mixture is normocapnic air (O₂, 21%; N₂, 79%). A, Mean arousal latency for each group of animals with Vglut2 deletions in the PB complex, calculated from the point when the channels were switched. B, Time course of arousals for each group. C, Percentage of trials that showed arousal latencies of >15, 30, and 40 s. The numbers were quite similar for all groups, indicating that the Vglut2 deletions did not affect the likelihood of the animals waking up spontaneously during a 100 s period of observed sleep. This figure represents the normocapnic responses of the animals, which were then tested for arousals to hypercapnia and hypoxic hypercapnia as shown in Figures 6 and 7.