Table 3. Selected examples of multi-factorial neurological diseases modeled with patient-specific iPSCs.

Disease	Genetic defects	iPSC-derived cell types	Phenotype demonstrated	Genetic rescue	Drug test	References
Sporadic Parkinson's disease (sPD)	Unknown	Dopaminergic neurons	Fewer and less branched neurites, and autophagic compromise.	No answer	No	45
Sporadic Alzheimer's disease (sAD)	Unknown	Neurons	Higher levels of the pathological markers in one out of two patient-derived neural cells.	No answer	Yes	30
Schizophrenia (SCZD)	Unknown	Neurons	Decreased neuronal connectivity, fewer neurites, and decreased PSD95, glutamate receptor expression.	No answer	Yes	51
Multiple sclerosis (MS)	Unknown	Neurons	Neurons appear functional but have somewhat different electrophysiological characteristics than controls.	No answer	Yes	28