Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2013 May 20;34(6):732–740. doi: 10.1038/aps.2013.27

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2013 CPS and SIMM

This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

PMC Copyright notice

Signal pathways related with cancer stem cells. Dysregulation of signal pathway network plays an important role in retaining the stemness of CSCs. Pathways and elements involved in the control of self-renewing and differentiation of cancer stem cells as well as normal stem cells include PI3K/Akt, JAK/STAT, Wnt/β-catenin, hedgehog, Notch, NF-κB, ABC superfamily and so on. Depending on these aberrant pathways, cancer stem cells acquire its unique ability to initiate carcinoma and promote recurrence after surgery.