Table 1. Summary of cardiomyocytes directed differentiation of hPSCs.
| Cell line | Terminal cells | Additional factors | Efficiency | Author |
|---|---|---|---|---|
| H7 human ESCs | Cardiomyocytes | Activin A, BMP4 | >30% | Laflamme et al 200723 |
| Human ESCs (H1, HES2) | Cardiomyocytes | BMP4, activin A, bFGF, VEGF, DKK1, | ∼50% | Yang et al 200824 |
| Human ESCs (H9, H13, H14); hiPSCs | Cardiomyocytes | β-catenin shRNA, activin A, BMP4, CHIR99021, or IWP2 | >82% | Lian et al 201225 |
| Human ESCs (H9) | Cardiomyocytes | BMP4, activin A, bFGF, VEGF, DKK1, ITD-1 | ∼60% | Willems et al 201226 |
| Human ESCs (H1, H9); hiPSCs | Cardiomyocytes | Activin A, BMP4, bFGF | ∼98% | Zhang et al 201227 |