Table 3.
Bioconcentration factors of diclofenac in present fish study compared to published studies
| Exposure period | Fish species and exposed life stage | BCF determined in | Test concentration (µg/L) | BCF | Reference |
|---|---|---|---|---|---|
| 10 d | Rainbow trout 1 year | Bile | 1.7 | 320–950 | Kallio et al. 18a |
| 10 d | Rainbow trout 1 year | Bile, blood plasma | 1.8/43 | 476/797, 5.7/4.9 | Lahti et al. 19b |
| 14 d | Rainbow trout 6 months | Blood plasma, liver | 1.6–81.5 | 4.0, 2.5 | Cuklev et al. 25b |
| 14 d | Rainbow trout young (1.1–1.2 g wet wt) | Whole fish | 2.1/18.7 | 5/3 | Present studyc |
| 21 d | Rainbow trout adult | Bile | 0.5/5/25 | 657/534/509 | Mehinto et al. 13b |
| 28 d | Rainbow trout 22 months | Liver | 1.06–501.2 | 12–2,732 | Schwaiger et al. 10b |
| kidney | 5–971 | ||||
| gills | 3–763 | ||||
| muscle | 0.3–69 |
a
BCF related to sum of diclofenac and metabolites.
b
BCF related to diclofenac only.
c
BCF related to sum of diclofenac and metabolites (total radioactivity measured).
BCF = bioconcentration factor.