Table 4.
NOEC's (in µg/L) for histopathological effects of diclofenac in fish organs
| Schwaiger et al. 10 | Hoeger et al. 12 | Mehinto et al. 13 | Praskova et al. a | Present study | |
|---|---|---|---|---|---|
| Liver | ≥500 | 0.5 | ≥25 | ≥60,000 | ≥1,000 |
| Kidney | 1 | 5 | 1 | ≥60,000 | ≥1,000 |
| Gills | 1 | 5 | — | ≥60,000 | 320 |
| Skin | — | — | — | ≥60,000 | — |
| Gastro-intestinal tract | ≥500 | — | 1–5 | — | — |
| Spleen | ≥500 | — | — | — | — |
| Exposure period | 28 d | 21 d | 21 d | 28 d | 95 d |
| Fish species | Rainbow trout | Brown trout | Rainbow trout | Zebrafish | Rainbow trout |
a
E. Praskova et al., University of Veterinary and Pharmaceutical Sciences Brno, Department of Veterinary Public Health and Toxicology, Brno, Czech Republic, unpublished manuscript.
NOEC = no observed effect concentration; — = not examined; ≥ = no effect up to and including the highest test concentration.