Table 3.
Clinical parameters of the study samples stratified based on the FSHR rs6166 genotype of the participants
| Parametera | FSHR rs6166 | Baltic male cohort (n = 1052) | All infertility patients (n = 738)b | Oligozoospermic patients (n = 684)b |
|---|---|---|---|---|
| FSH (IU/L) | A/A | 3.0 ± 1.6 | 8.2 ± 8.5 | 7.1 ± 6.0 |
| 2.6 (1.1–5.9) | 5.6 (1.9–25.6) | 5.4 (1.8–19.7) | ||
| A/G | 3.2 ± 1.7 | 8.5 ± 8.2 | 7.0 ± 5.6 | |
| 2.8 (1.1–6.6) | 5.6 (1.8–25.2) | 5.3 (1.7–18.8) | ||
| G/G | 3.1 ± 1.8 | 9.9 ± 7.8 | 9.1 ± 6.9 | |
| 2.7 (1.3–6.1) | 7.0 (2.3–28.5) | 6.8 (2.3–23.9) | ||
| LH (IU/L) | A/A | 4.0 ± 1.6 | 4.7 ± 2.8 | 4.3 ± 2.0 |
| 3.8 (1.8–6.8) | 4.1 (1.7–9.6) | 4.1 (1.7–8.2) | ||
| A/G | 4.0 ± 1.6 | 4.5 ± 2.4 | 4.2 ± 1.9 | |
| 3.8 (1.8–7.1) | 3.9 (1.7–8.6) | 3.7 (1.6–7.6) | ||
| G/G | 4.1 ± 1.8 | 4.8 ± 2.3 | 4.7 ± 2.1 | |
| 3.9 (1.8–7.6) | 4.2 (2.0–9.2) | 4.2 (2.0–8.6) | ||
| Inhibin B (pg/mL) | A/A | 233.8 ± 75.8 | 90.6 ± 51.7 | 94.6 ± 50.6 |
| 226.5 (121.9–381.2) | 91.5 (10.1–180.3) | 93.8 (10.6–182.9) | ||
| A/G | 223.1 ± 76.7 | 92.6 ± 66.8 | 98.2 ± 66.1 | |
| 212.0 (112.3–361.7) | 76.7 (13.9–214.8) | 81.0 (23.5–223.9) | ||
| G/G | 233.4 ± 86.6 | 73.8 ± 52.3 | 75.1 ± 52.8 | |
| 222.0 (109.2–397.6) | 53.9 (10.0–175.1) | 53.9 (10.0–175.2) | ||
| Total testosterone (nmol/L) | A/A | 28.4 ± 8.6 | 19.2 ± 7.0 | 19.2 ± 7.0 |
| 27.8 (14.9–44.7) | 18.5 (9.8–32.0) | 18.5 (9.8–31.0) | ||
| A/G | 27.1 ± 9.7 | 18.3 ± 6.4 | 18.3 ± 6.2 | |
| 25.8 (14.4–44.2) | 17.7 (9.8–30.2) | 17.7 (10.1–30.4) | ||
| G/G | 27.3 ± 8.8 | 18.1 ± 5.9 | 18.3 ± 5.9 | |
| 26.0 (15.2–45.4) | 17.7 (10.4–28.6) | 17.7 (10.3–28.8) | ||
| Estradiol (pmol/L) | A/A | 96.2 ± 26.8 | 102.9 ± 42.3 | 103.0 ± 43.0 |
| 92.0 (59.0–145.0) | 87.7 (73.0–172.7) | 86.5 (73.0–172.6) | ||
| A/G | 93.5 ± 25.4 | 99.4 ± 35.9 | 98.9 ± 33.6 | |
| 89.0 (60.0–140.7) | 87.0 (73.0–159.3) | 87.0 (73.0–157.0) | ||
| G/G | 93.3 ± 21.3 | 99.0 ± 30.4 | 99.5 ± 30.6 | |
| 91.0 (56.5–131.1) | 89.7 (73.0–163.7) | 90.3 (73.0–164.2) | ||
| Total testes volume (mL) | A/A | 50.4 ± 10.5 | 40.7 ± 11.8 | 41.3 ± 11.7 |
| 50.0 (33.0–70.0) | 41.0 (23.0–59.9) | 41.0 (24.0–60.0) | ||
| A/G | 48.5 ± 10.0 | 39.5 ± 9.8 | 40.3 ± 9.1 | |
| 50.0 (33.0–65.0) | 40.0 (22.0–55.0) | 40.0 (24.0–55.9) | ||
| G/G | 48.3 ± 10.1 | 37.6 ± 9.4 | 38.4 ± 8.9 | |
| 48.0 (32.0–70.0) | 36.0 (22.1–53.8) | 37.0 (23.7–54.0) | ||
| Semen volume (mL) | A/A | 3.4 ± 1.6 | 4.4 ± 1.9 | 4.3 ± 1.9 |
| 3.1 (1.3–6.4) | 4.0 (1.9–8.1) | 4.0 (1.8–8.1) | ||
| A/G | 3.5 ± 1.6 | 4.1 ± 1.8 | 4.2 ± 1.8 | |
| 3.4 (1.3–6.5) | 3.9 (1.4–7.6) | 4.0 (1.4–7.6) | ||
| G/G | 3.5 ± 1.6 | 4.0 ± 1.6 | 4.0 ± 1.6 | |
| 3.4 (1.1–6.5) | 3.8 (1.4–7.2) | 3.8 (1.6–7.2) | ||
| Sperm concentration (106/mL) | A/A | 80.4 ± 66.9 | 7.1 ± 5.8 | 7.6 ± 5.7 |
| 64.8 (7.8–212.2) | 6.2 (0.0–17.0) | 7.0 (0.2–17.0) | ||
| A/G | 83.0 ± 81.2 | 6.9 ± 6.0 | 7.5 ± 5.9 | |
| 62.5 (9.0–223.7) | 5.0 (0.0–18.0) | 6.0 (0.1–18.0) | ||
| G/G | 78.4 ± 66.3 | 7.1 ± 6.5 | 7.6 ± 6.5 | |
| 62.3 (12.2–181.4) | 5.1 (0.0–18.0) | 5.6 (0.1–18.2) | ||
| Total sperm count (106) | A/A | 267.2 ± 251.6 | 31.4 ± 30.4 | 33.5 ± 30.3 |
| 202.2 (18.8–718.9) | 23.0 (0.0–89.1) | 25.6 (0.5–91.6) | ||
| A/G | 280.4 ± 291.9 | 30.2 ± 31.9 | 33.0 ± 31.9 | |
| 210.9 (16.6–767.4) | 18.0 (0.0–93.8) | 22.7 (0.3–94.9) | ||
| G/G | 266.5 ± 278.0 | 29.0 ± 31.1 | 30.8 ± 31.2 | |
| 213.3 (26.0–671.2) | 18.9 (0.0–95.7) | 20.0 (0.4–95.9) |
a
Data are presented as mean ± SD and median (5–95th percentile).
b
Clinical parameters of azoospermic patients (n = 54) stratified based on the FSHR rs6166 genotype are presented in Supporting Table 1.