Figure 1.
Swiss CF newborn screening protocol after adjustments in the first pilot year. This protocol has been in use since 1 January 2012. The following four adjustments to the protocol were made in the first pilot year:
The IRT cutoff value was raised from 45 to 50 ng/mL;
A second heel prick test was performed only if the initial IRT was 60 ng/mL or higher, without any CF gene mutation on screening.
If the sweat test did not yield a valid result, genetic analysis was performed immediately and the sweat test was repeated later.
Children with meconium ileus had genetic screening at the same time as IRT measurement.
CF, cystic fibrosis; IRT, immunoreactive trypsinogen;
NBS, newborn screening
