. Author manuscript; available in PMC: 2014 May 1.

Published in final edited form as: J Immunol. 2013 Apr 1;190(9):4707–4716. doi: 10.4049/jimmunol.1203465

Table III.

Sensitivity Analysis Results fixing antigen dose.

NAME	LOW DOSE	HIGH DOSE
CD4 in the Lymph Node		IL10 half saturation on delaying IDC maturation (Lung) [hs_I10-DC] (+) IL10 half saturation on delaying precursor Th1 proliferation (LN) [hs_I10-T0LN] ^(*) (+)
CD8 in the Lymph Node	Max IDC infection/uptake rate in the LN ^()(+)[k_12a]; Rate (likelihood) of Naïve CD4+ T cell priming when encountering a MDC (LN)[k₁₄] ^()(+); Scaling factor between lung and LN compartments [ϒ] ^(*)(-);	IL10 half saturation on delaying IDC maturation (Lung) [hs_I10-DC] (+) IL10 half saturation on delaying precursor Th1 proliferation (LN) [hs_I10-T0LN] ^() (+) MDC migration rate from the lung to the LN [φ] ^()(+)
CD4 in the Lung		IL10 half saturation on delaying IDC maturation (Lung) [hs_I10-DC] (+)
CD8 in the Lung	Max IDC infection/uptake rate in the LN^() (+) [k_12a]; Rate (likelihood) of Naïve CD4+ T cell priming when encountering a MDC (LN)[k₁₄] ^()(+); Scaling factor between lung and LN compartments [ϒ](+);	IL10 half saturation on delaying IDC maturation (Lung) [hs_I10-DC] (+)

Important mechanisms affecting priming (CD4s and CD8+ Ts) that resulted uniquely significant (p<0.001) for either high or low dose LHS experiments. Only either PRCCs>0.15 or PRCCs<-0.15 are shown. The sign of the correlation is in parenthesis.

^(*)

significant only in the first 10 days post infection.