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. 2012 Nov 1;14(6):R238. doi: 10.1186/ar4081

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Copyright ©2012 Horvath et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Identification of primary Sjögren's syndrome disease-related gene modules revealed by weighted gene co-expression network analysis. Barplots showing the mean value of the module eigengene (y axis) versus human disease progression status (x axis) where 0 denotes healthy controls, 1 denotes nonprimary Sjögren's syndrome (non-pSS) sicca patients, and 2 denotes pSS patients. Kruskal-Wallis test P values above the plots show that the module eigengenes of all four modules - Magenta (576 genes), Brown (2,502 genes), Grey60 (216 genes), and Light-Cyan (349 genes) - are significantly overexpressed in pSS patients compared with both non-pSS sicca patients and controls.