Table 1.

Overall statistical power of the study for KCNA5 rs10744676 SNP in each analyzed disease subtype at the 5% significance level assuming an additive effect model and a minor allele (rs10744676*C) frequency = 0.10 (MAF_CEU)

	Phenotype
Statistical power (%)	SSc	lcSSc	dcSSc	ACA+	ATA+	Fib+	PAH+
OR = 0.62	100	100	99	100	96	99	95a
OR = 0.48	100	100	100	100	100	100	100b
OR = 0.79	96	91	67	77	59	71	45c

^aReference OR, 0.62, except for the PAH⁺ group, in which OR = 0.47. ^bReference OR (lower previously reported 95% CI) = 0.48, except for the PAH⁺ group, in which OR = 0.32. ^cReference OR (upper previously reported 95% CI) = 0.79, except for the PAH⁺ group, in which OR = 0.71. SSc, systemic sclerosis; lcSSc, limited cutaneous systemic sclerosis; dcSSc, diffuse cutaneous systemic sclerosis; ACA⁺, anti-centromere autoantibody-positive patients; ATA⁺, anti-topoisomerase autoantibody-positive patients; Fib⁺, lung fibrosis-positive patients (HRCT); PAH⁺, pulmonary arterial hypertension-positive patients (right-heart catheterization).