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. 2012 Nov 22;14(6):R253. doi: 10.1186/ar4096

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Copyright ©2012 Haynes et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Bone matrix proteins in affected proteoglycan-induced spondylitis (PGISp) mouse vertebrae. In an unaffected sacral joint, collagen type I (A) (×40) and osteocalcin (B) (×40) immunohistochemical staining clearly delineate the bone compartment, only staining the vertebral bone. Collagen type I staining is evident at the fringes of the excess matrix in an affected joint however (D) (×40), (boxed area in E) (×200). This collagen matrix is only osteocalcin-positive at the outermost periphery (F) (×40), (boxed area in G) (×200,). Rabbit immunoglobulin (IgG)-negative control shows no background staining (C) (×40).