Table 3.
Haplotype frequencies and meta-analysis of PADI4 polymorphisms in relation to RA in the MyEIRA study
| Block | Ethnicity | Haplotype frequency | Ratio counts (case, control) | Frequencies (case, control) | χ 2 | P value | OR (95% CI) | Meta-analysis | P het | I2 (%) |
|---|---|---|---|---|---|---|---|---|---|---|
| ACGG | Malay | 0.501 | 510.8:537.2, 984.2:951.8 | 0.487, 0.508 | 1.195 | 0.2744 | 0.92 (0.79 to 1.07) | 0.91 (0.82 to 1.02), Z = 1.62 (P = 0.10) | 0.64 | 0 |
| Chinese | 0.567 | 288.8:217.2, 224.7:175.3 | 0.571, 0.562 | 0.076 | 0.7835 | 1.04 (0.80 to 1.35) | ||||
| Indian | 0.413 | 292.7:453.3, 246.1:313.9 | 0.392, 0.439 | 2.919 | 0.0875 | 0.83 (0.66 to 1.03) | ||||
| Others | 0.46 | 78.8:97.2, 88.6:99.4 | 0.447, 0.471 | 0.204 | 0.6519 | 0.91 (0.60 to 1.37) | ||||
| ATAA | Malay | 0.055 | 42.5:1,005.5, 120.7:1,815.3 | 0.041, 0.062 | 6.226 | 0.0126 | 0.64 (0.45 to 0.92) | 0.71 (0.54-0.94), Z = 2.42 (P = 0.02) | 0.78 | 0 |
| Chinese | 0.064 | 29.0:477.0, 29.0:371.0 | 0.057, 0.073 | 0.86 | 0.3537 | 0.78 (0.46 to 1.32) | ||||
| Indian | 0.015 | 9.7:736.3, 9.3:550.7 | 0.013, 0.017 | 0.293 | 0.5886 | 0.83 (0.34 to 2.06) | ||||
| Others | 0.039 | 7.3:168.7, 7.0:181.0 | 0.042, 0.037 | 0.046 | 0.8296 | 1.07 (0.37 to 3.12) | ||||
| ATAG | Malay | 0.287 | 333.6:714.4, 522.9:1,413.1 | 0.318, 0.270 | 7.736 | 0.0054 | 1.26 (1.07 to 1.49) | 1.21 (1.08-1.36), Z = 3.20 (P = 0.001) | 0.78 | 0 |
| Chinese | 0.274 | 140.8:365.2, 107.1:292.9 | 0.278, 0.268 | 0.128 | 0.7202 | 1.06 (0.79 to 1.42) | ||||
| Indian | 0.398 | 312.4:433.6, 207.6:352.4 | 0.419, 0.371 | 3.09 | 0.0788 | 1.22 (0.97 to 1.52) | ||||
| Others | 0.34 | 62.5:113.5, 61.4:126.6 | 0.355, 0.326 | 0.336 | 0.562 | 1.16 (0.75 to 1.79) | ||||
| ATGG | Malay | 0.096 | 108.7:939.3, 178.8:1,757.2 | 0.104, 0.092 | 1.001 | 0.317 | 1.14 (0.89 to 1.46) | 1.02 (0.77-1.36), Z = 0.14 (P = 0.89) | 0.24 | 29 |
| Chinese | 0.046 | 23.2:482.8, 18.3:381.7 | 0.046, 0.046 | 0.0 | 0.9908 | 1.01 (0.54 to 1.90) | ||||
| Indian | 0.049 | 39.1:706.9, 25.3:534.7 | 0.052, 0.045 | 0.351 | 0.5538 | 1.18 (0.71 to 1.97) | ||||
| Others | 0.091 | 11.0:165.0, 22.0:166.0 | 0.063, 0.117 | 3.268 | 0.0706 | 0.50 (0.24 to 1.07) | ||||
| GTAG | Malay | 0.041 | 38.6:1,009.4, 83.8:1,852.2 | 0.037, 0.043 | 0.714 | 0.398 | 0.85 (0.58 to 1.26) | 0.94 (0.72-1.21), Z = 0.49 (P = 0.63) | 0.59 | 0 |
| Chinese | 0.042 | 20.1:485.9, 17.9:382.1 | 0.040, 0.045 | 0.138 | 0.7099 | 0.87 (0.46 to 1.67) | ||||
| Indian | 0.065 | 47.9:698.1, 37.1:522.9 | 0.064, 0.066 | 0.023 | 0.8798 | 0.97 (0.62 to 1.51) | ||||
| Others | 0.046 | 10.4:165.6, 6.4:181.6 | 0.059, 0.034 | 1.326 | 0.2496 | 1.83 (0.65 to 5.14) | ||||
CI, confidence interval; I2, degree of heterogeneity (%); MyEIRA, Malaysian Epidemiological Investigation of Rheumatoid Arthritis; OR, odds ratio; PADI, peptidylarginine deiminase; Phet, P value for heterogeneity; RA, rheumatoid arthritis.