Table 1.
Effects of 1,000 μmol/l sodium ferulate on apoptosis-related gene expression in rat osteoarthritis chondrocytes.
| Gene | Model control/normal control (20 ng/ml vs. 0 ng/ml IL-1β) | SF treatment/model control (1,000 μmol/l vs. 0 μmol/l SF in presence of 20 ng/ml IL-1β) |
|---|---|---|
| TNF/TNFR pathway | ||
| TNF | 30.07 | 0.64 |
| TNFR-1b | 3.04 | 0.39 |
| TRAF-2 | 2.50 | 0.43 |
| TRADD | 1.98 | 0.69 |
| Caspase-8 | 2.30 | 0.43 |
| Caspase-3 | 1.88 | 0.46 |
| NF-κB | 2.55 | 0.56 |
| Other pathways | ||
| Fas | 1.85 | 1.00 |
| Fas ligand | 0.45 | 0.42 |
| FADD | 0.94 | 0.58 |
| Bcl-2 | 0.75 | 0.59 |
| Bax | 0.61 | 0.66 |
| Bax/Bcl-2 | 0.80 | 1.12 |
| Apaf1 | 0.76 | 1.03 |
| Caspase 9 | 0.53 | 0.48 |
Each reported value represents the mean fold of mRNA expression relative to the control levels for three biological replicates. FADD, Fas-associated death domain protein; SF, sodium ferulate; TNFR, tumor necrosis factor receptor; TRADD, TNF receptor-associated death domain; TRAF, TNF receptor-associated factor.