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. Author manuscript; available in PMC: 2013 Jun 6.
Published in final edited form as: Cell Rep. 2013 May 9;3(5):1607–1616. doi: 10.1016/j.celrep.2013.04.009

Figure 4. Systematic assessment of the performance of different polarity network topologies in buffering back polarity.

Figure 4

A. Set of possible additional links (blue dashed lines) to the core topology (black lines). B. Schema of additions: one, two, or three positive or negative links. C–D. Heat map of changes to the buffering performance upon addition of direct (C) or indirect (D) links. Heat map color scale: change to the buffering between the new and the original topologies (i.e. link vs. no link). Color bar: cyan or yellow indicates decreased or increased (respectively) buffering capability compared to the core topology. Green shaded background: topologies with best overall buffering performance for both direct and indirect model implementations. Gray shaded background: topologies where the back was excessively “squeezed” into a narrow region. See also Figure S4B–C and Table S3.