Table 4.
SNP genotype association with alloimmunization in SCD.
| SNP | Gene | Genotypes | Number of patients* | P value | HapMap# | |
|---|---|---|---|---|---|---|
| Antibody positive | Antibody negative | |||||
| (1) rs1049388 | ARHG | CC/CG/GG | 21/8/0 | 21/11/0 | 0.593273 | 62/30/8 |
| (2) rs1451724 | ARHG | AA/AG/GG | 1/3/27 | 0/3/29 | 0.833054 | 0/23/77 |
| (3) rs4910852 | ARHG | AA/AG/GG | 25/7/0 | 18/10/0 | 0.264449 | 61/30/9 |
| (4) rs7128013 | ARHG | AA/AC/CC | 13/12/5 | 11/18/4 | 0.543399 | 25/49/26 |
| (5) rs7929197 | ARHG | CC/CT/TT | 7/13/12 | 8/12/5 | 0.429608 | 30/45/25 |
| (6) rs10742177 | ARHG | CC/CG/GG | 10/14/7 | 18/3/5 | 0.008979 | 41/45/14 |
| (7) rs10835182 | ARHG | AA/AT/TT | 0/14/15 | 0/12/20 | 0.444898 | 2/23/75 |
| (8) rs10835184 | ARHG | AA/AT/TT | 25/2/0 | 26/2/2 | 0.550071 | 95/5/0 |
| (9) rs12272393 | ARHG | AA/AC/CC | 7/13/14 | 8/12/11 | 0.817062 | 30/45/25 |
| (10) rs17173879 | ARHG | AA/AG/GG | 30/2/0 | 25/1/0 | 0.999999 | 93/7/0 |
|
| ||||||
| (11) rs2231529 | CHRNA | CC/CT | 27/3/1 | 35/2/0 | 0.493847 | 93/7/0 |
| (12) rs2231532 | CHRNA | AA/AG/GG | 19/13/3 | 14/12/5 | 0.609984 | 63/35/2 |
| (13) rs2271583 | CHRNA | AA/AG/GG | 4/14/15 | 2/9/18 | 0.422893 | 10/33/57 |
| (14) rs2672213 | CHRNA | CC/CT/TT | 30/2/0 | 23/4/0 | 0.397881 | 97/3/0 |
| (15) rs2672216 | CHRNA | CC/CT/TT | 32/2/0 | 25/8/1 | 0.062890 | 85/13/2 |
| (16) rs2741862 | CHRNA | CC/CT/TT | 5/25/4 | 14/14/5 | 0.022396 | 23/35/42 |
| (17) rs12221525 | CHRNA | CC/CG/GG | 20/8/4 | 20/11/2 | 0.562563 | 50/37/13 |
|
| ||||||
| (18) rs708564** | CD81 | CC/CT/TT | 5/15/11 | 23/8/3 | 0.000086 ## | 82/17/2 |
| (19) rs731909 | CD81 | CC/CG/GG | 27/6/3 | 33/2/0 | 0.064002 | 90/8/2 |
| (20) rs756915 | CD81 | CC/CT/TT | 9/19/8 | 12/14/10 | 0.495260 | 21/50/29 |
| (21) rs800137 | CD81 | CC/CT/TT | 6/16/13 | 14/14/7 | 0.086688 | 46/31/24 |
| (22) rs800335 | CD81 | CC/CT/TT | 7/10/18 | 4/8/24 | 0.374866 | 82/17/2 |
| (23) rs874330 | CD81 | CC/CT/TT | 13/15/7 | 19/9/7 | 0.284287 | 52/40/8 |
| (24) rs2019938 | CD81 | AA/AG/GG | 11/13/5 | 15/14/8 | 0.851861 | 43/33/23 |
| (25) rs2237863 | CD81 | CC/CT/TT | 3/22/5 | 15/10/6 | 0.001518 ## | 15/47/38 |
| (26) rs11022565 | CD81 | GG/GT/TT | 17/14/4 | 21/7/5 | 0.280369 | 61/32/7 |
| (27) rs11022567 | CD81 | AA/AG/GG | 5/14/16 | 5/7/25 | 0.120284 | 7/33/60 |
*Patient numbers are displayed in the order shown in the column labeled genotypes. #Relative distribution of genotypes in Sub-Saharan population, as reported by the HapMap. This research utilizes the NCBI SNP database [41], (http://www.ncbi.nih.gov/snp/). The Single Nucleotide Polymorphism database (dbSNP) is a public domain archive for a broad collection of simple genetic polymorphisms. dbSNP reports many cases of SNPs genotyped by HapMap and other projects which provide additional genotype and allele frequency information. **NCBI database describes two additional alleles, A/G with very low frequencies (<0.5%) for rs708564. This might be due to a mutational mechanism that leads to the simultaneous creation of two new base pairs at the same site which is beyond the scope of this study [42]. Our results, however, are based on the two reference SNPs alleles (C/T) of rs708564. ## P values significant comparing SCD patients with and without alloimmunization.