Table 5.
Hbβ S genotypes in SCD patients with or without antibodies or with “informative” SNP genotypes.
| Hbβ S haplotype | Total patients | Antibody positive | Antibody negative | P value | ||
|---|---|---|---|---|---|---|
| At least one C/C genotype* | No C/C genotypes* | At least one C/C genotype* | No C/C genotypes* | |||
| Bantu/Bantu | 15 | 2 | 6 | 7 | 0 | 0.0069 |
| Benin/Benin | 28 | 1 | 10 | 12 | 5 | 0.0021 |
| Other** | 33 | 3 | 13 | 11 | 5 | 0.0113 |
|
| ||||||
| Total | 75 | 6 | 29 | 30 | 10 | 6.17 × 10−7 |
*Patients were divided into groups that had rs708564C/C and/or rs22378563C/C genotypes (group one) or were double negative for these genotypes (group two).
**Includes any haplotypes found in 10 or less subjects (Senegal/Senegal; Benin/Cameroon; Senegal/Benin; Cameroon/Cameroon; Benin/Bantu; Bantu/Cameroon; Senegal/Cameroon; Benin/βthal; and Senegal/βthal).