Table 1.
Summary of CXCL13 and IL-10 levels in CSF of patients with PCNSL and SCNSL, neuro-inflammatory conditions, other malignant brain tumors, and neoplasms or infection outside of the brain/CSF
| Diagnosis | N | Age | Gender | CXCL13 (pg/mL) | IL-10 (pg/mL) |
|---|---|---|---|---|---|
| New diagnosis PCNSL | 43 | 60 | 19 M/24 F | 996 ± 312 | 282.9 ± 113 |
| New diagnosis SCNSL | 10 | 57 | 5 M/5 F | 539 ± 157 | 57 ± 37 |
| Recurrent PCNSL | 17 | 55 | 6 M/11 F | 5926.2 ± 2030 | 1003 ± 483 |
| Recurrent SCNSL | 13 | 58 | 10 M/3 F | 1783 ± 896 | 302 ± 126 |
| Neuro-inflammatory/infection | 71 | 45 | 44 M/27 F | 44.9 ± 19 | 5.6 ± 2.33 |
| Other primary brain tumors | 8 | 40.5 | 5 M/3 F | 84.5 ± 60.7 | 10.9 ± 5.6 |
| Metastatic brain tumors | 12 | 54.5 | 2 M/10 F | 58.46 ± 41.6 | 5.3 ± 1.5 |
| Neoplasm/infection outside of brain | 46 | 45 | 29 M/17 F | 11 ± 3.6 | 3.6 ± 1.4 |
All CSF from newly diagnosed patients was obtained via lumbar puncture. Age refers to median age of each cohort. CXCL13 and IL-10 levels in CSF from individual patients are provided in supplemental Tables 1-3.
M, male; F, female.