Table 2.

Bivariate elevation of both CXCL13 and IL-10

Biomarker	Sensitivity	Specificity	AUC	CI
CXCL13	71%	95%	0.841	0.779-0.892
IL-10	64%	94.1%	0.851	0.789-0.901
CXCL13 or IL-10	84.2%	90.5%	0.874	0.815-0.919
CXCL13 plus IL-10	50%	99.3%	0.746	0.675-0.809
Cytology	14%	Reference standard	Reference standard	Reference standard
Flow cytometry	20%	Reference standard	Reference standard	Reference standard

Bivariate elevation of both CXCL13 and IL-10 is more than twice as sensitive as cytology (P < .001) and flow cytometry (P < .05), with equivalent specificity, in the detection of non-HIV–associated PCNSL at diagnosis (Fisher’s exact test [2-tailed]). An algorithm based on detection of elevation of either CXCL13 or IL-10 in CSF is more than 3 times as sensitive compared with the reference standard tests (P < .0001).