Table 3.
Inhibitory effect of YPEE on high-fat diet-induced cholesterol, TG, resistin, leptin, glucose, and insulin resistance (HOMA-IR).
| ND | HFD | YPEEL | YPEEH | |
|---|---|---|---|---|
| Initial body weight (g) | 20.2 ± 1.1 | 19.9 ± 0.8 | 20.1 ± 0.9 | 18.9 ± 1.2 |
| Final body weight (g) | 27.8 ± 1.6 | 40.4 ± 2.0a | 38.4 ± 3.8 | 32.4 ± 2.4b |
| HOMA-IR | 1.95 ± 0.5 | 26.2 ± 5.4a | 24.2 ± 6.4b | 7.91 ± 3.3b |
| Glucose (mg/dL) | 115 ± 3 | 187 ± 9a | 195 ± 8b | 174 ± 11b |
| Serum | ||||
| Resistin (ng/mL) | 17.5 ± 1.9 | 29.9 ± 2.1a | 29.8 ± 3.3 | 20.6 ± 1.8b |
| Leptin (ng/mL) | 1.6 ± 0.2 | 14.0 ± 1.6a | 10.1 ± 1.5b | 3.7 ± 0.9b |
| Total cholesterol (mg/dL) | 79.1 ± 3.0 | 92.0 ± 3.1a | 77.6 ± 1.7b | 74.2 ± 1.2b |
| Triglyceride (mg/dL) | 68.4 ± 9.8 | 78.5 ± 6.4a | 75.6 ± 4.8 | 67.5 ± 8.4b |
| Insulin (ng/mL) | 0.23 ± 0.05 | 1.85 ± 0.33a | 1.64 ± 0.39b | 0.58 ± 0.21b |
ND: normal diet; HFD: high-fat diet; YPEEL: high-fat diet plus 1% ethanol extract of yuja peel/kg diet; YPEEH, high-fat diet plus 5% ethanol extract of yuja peel/kg diet. Data are expressed as mean ± SD (n = 8). a P < 0.05 versus ND; b P < 0.05 versus HFD.