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. 2013 Jun 3;210(6):1153–1165. doi: 10.1084/jem.20122248

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© 2013 Sitrin et al.

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Figure 6. — IL-2 production in the pancreas before and after T reg ablation. (A) Representative flow cytometry plots for pancreatic infiltrate from BDC2.5/NOD mice stained and analyzed for IL-2 by intracellular flow cytometry. An extended FSC/SSC gate was taken to include both lymphocytes and leukocytes along with a live/dead stain to exclude dead cells. CD45⁺IL-2⁺ cells were analyzed for CD3 and CD4 expression. (B) Summary data for pancreatic infiltrate from mice depleted of T reg cells (8 h with DT, DTR⁺) or not (8 h with DT, DTR⁻). Mean ± SD, at least three independent experiments. (C) Summary data, as in B, gated on CD4⁺ T cells.