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. 2013 Jun 3;210(6):1137–1151. doi: 10.1084/jem.20122344

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© 2013 Roberts et al.

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Figure 5. — The transplanted C26 carcinoma, cachexia, and systemic alterations in FAP⁺ stromal cells. (A) Whole body weight and food intake of C57BL/6 × BALB/c F1 mice with and without ectopic C26 tumors were measured during the 3–4-wk post-tumor implantation period. (B) C26 cells were subcutaneously inoculated into BAC transgenic C57BL/6 × BALB/c F1 mice. Whole body bioluminescence was quantified for the entire dorsal surface of the mice at the indicated times. (C) The levels of bioluminescence of the excised C26 tumor and several tissues of tumor-bearing mice and littermate controls were assessed. (B and C) Scale represents relative counts. Error bars represent SEM. Data are representative of three independent analyses (n = 4 for A and B; representative n = 1 for C).