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. 2013 Jun 3;210(6):1137–1151. doi: 10.1084/jem.20122344

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© 2013 Roberts et al.

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Figure 7. — Alterations of FAP⁺ cells in the quadriceps muscle and bone marrow of KPC mice with PDA. (A and B) The quadriceps muscles from PDA-bearing KPC mice with and without cachexia and littermates were assessed for mass (A) and the mRNA levels of atrogin-1 MuRF1, FAP, Fst, Lama2, and Mstn (B). (C) Peripheral blood from PDA-bearing mice and nontumor-bearing littermates was assayed for hemoglobin, erythrocyte number, mean corpuscular hemoglobin, and mean corpuscular volume. (D) Individual populations of hematopoietic cells from the femoral bone marrow of PDA-bearing mice and nontumor-bearing littermates were assessed by flow cytometry. (E) The levels of Cxcl12 and KitL protein in lysates of cells recovered from the femoral bone marrow of PDA-bearing KPC mice and nontumor-bearing littermates were measured by ELISA. (F) The mRNA levels of FAP in heart and salivary glands from KPC, PDA-bearing mice with and without cachexia and littermates were assessed by qRT-PCR. Error bars represent SEM. *, P < 0.05; **, P < 0.01; ***, P < 0.001. Combined data are from three independent analyses (n = 1–5).