Table 3.
Effects of a High-Fat Diet (HFD) on Various Serum Biomarkers and Metabolic Parameters in Fasted Young and Aged C57BL/6 Mice
| Parameter | Young (SD) | Young (HFD) | Aged (SD) | Aged (HFD) |
|---|---|---|---|---|
| Total triglycerides (mg/dL) | 62.0±9.4 | 54.9±5.9 | 51.0±5.7 | 37.6±4.4 |
| Total cholesterol (mmol/L) | 5.4±0.5 | 6.7±0.6 | 3.7±0.1* | 3.6±0.3*,† |
| Glucose (mmol/L) | 6.6±0.4 | 11.0±0.7* | 6.7±0.3 | 9.5±0.9*,‡ |
| Leptin (ng/mL) | 1.2±0.2 | 50.8±7.0* | 0.4±0.1 | 15.4±0.6*,†,‡ |
| Adiponectin (µg/mL) | 7.4±0.6 | 8.0±0.8 | 6.0±0.6 | 4.0±0.5†,‡ |
| Insulin (ng/mL) | 0.5±0.3 | 1.1±0.1* | 0.3±0.1 | 0.7±0.1†,‡ |
| IGF-1 (ng/mL) | 465±78 | 233±30* | 201±22* | 251±34 |
| QUICKI | 0.358±0.006 | 0.272±0.003* | 0.350±0.006 | 0.290±0.010*,‡ |
Notes: Data are means ± SEM (n = 5–7 for each data point). QUICKI = quantitative insulin sensitivity check index.* p < .05 vs standard diet (SD)–fed young control mice.† p < .05 vs HFD-fed young mice.‡ p < .05 vs SD-fed aged mice.