Table 3.
Multivariate Associations of a Phenotype in Question (outcome) With Physiological Indices (predictors) in Parents, Their Children, and All Offspring
| Model | Phenotypes | Parents | Offspring* | Children† | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Outcome | Predictors | β | SE | p Value | β | SE | p Value | β | SE | p Value | |
| Model 1 | BMI | N = 1,277 | N = 2,159 | N = 1,400 | |||||||
| BG | 7.40 | 1.41 | 2.0E-7 | 12.24 | 1.384 | 1.3E-17 | 11.88 | 1.74 | 2.6E-11 | ||
| HDL-C | −6.39 | 1.07 | 4.8E-9 | −10.12 | 0.959 | 5.1E-23 | −9.98 | 1.19 | 2.0E-15 | ||
| TG | 3.35 | 0.62 | 2.1E-7 | 3.76 | 0.502 | 9.0E-13 | 3.69 | 0.63 | 2.0E-8 | ||
| SBP | 3.90 | 1.42 | 7.6E-3 | 10.69 | 1.609 | 2.8E-10 | 11.86 | 2.04 | 5.0E-8 | ||
| Model 2 | Htn | N = 1,281 | N = 2,164 | N = 1,410 | |||||||
| BMI | 9.2E-3 | 3.4E-3 | 6.1E-3 | 1.6E-2 | 2.2E-3 | 4.5E-13 | 1.7E-2 | 2.7E-3 | 4.6E-10 | ||
| BG | 1.8E-1 | 1.7E-1 | 3.0E-1 | 4.6E-1 | 1.4E-1 | 1.7E-03 | 5.0E-1 | 1.8E-1 | 5.5E-3 | ||
| HDL-C | 1.5E-1 | 1.3E-1 | 2.5E-1 | 1.0E-1 | 1.0E-1 | 3.1E-01 | 1.4E-1 | 1.2E-1 | 2.6E-1 | ||
| TG | 8.8E-2 | 7.5E-2 | 2.4E-1 | 2.0E-1 | 5.2E-2 | 1.3E-04 | 2.4E-1 | 6.3E-2 | 2.3E-4 | ||
| Model 3 | T2D | N = 1,274 | N = 2,142 | N = 1,389 | |||||||
| BMI | 5.6E-3 | 2.0E-3 | 6.5E-3 | 6.9E-3 | 1.0E-3 | 5.4E-11 | 7.4E-3 | 1.2E-3 | 4.0E-9 | ||
| LDL-C | −1.1E-2 | 2.4E-3 | 6.2E-6 | −1.0E-2 | 1.4E-3 | 1.1E-11 | −8.7E-3 | 1.8E-3 | 1.5E-6 | ||
| TG | 1.3E-1 | 4.4E-2 | 2.8E-3 | 8.9E-2 | 2.3E-2 | 1.6E-04 | 9.7E-2 | 2.7E-2 | 5.0E-4 | ||
| SBP | 5.4E-3 | 1.3E-1 | 9.7E-1 | 4.3E-1 | 1.2E-1 | 3.4E-04 | 4.1E-1 | 1.5E-1 | 7.7E-3 | ||
| DBP | 1.3E-3 | 8.6E-3 | 8.8E-1 | −3.2E-2 | 6.9E-3 | 7.3E-06 | −3.2E-2 | 8.6E-3 | 4.1E-4 | ||
Notes: See notations and the models adjustments in Table 2.
*“Offspring” denotes children, nieces, and nephews of long-living individuals shown as “Parents.”
†“Children” denotes children of long-living individuals shown as “Parents.” Children with phenotypes presented for each model were excluded from the analyses if these phenotypes were not measured in their parents.