Figure 1.

Hydrocephalus and placental defect in Tgif mutant mice. (A) One-month-old Tgif/Tgif homozygous mutant mouse with hydrocephalus (indicated with an arrow). (B). Placentas from wild-type and mutant E13.5 embryos. No differences in size or morphology were observed. (C). Representative images of H&E stained sections through the centre of the placenta for each genotype combination. Eight M+/+E+/−, 10 M+/− E+/− and 9 M−/− E+/− placentas were analysed. Arrows and arrowheads indicate fetal and maternal blood spaces. The genotype of the mother (M) and the embryo (E) are indicated in the pictures and the sections.