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. 2013 Mar 13;22(13):2689–2704. doi: 10.1093/hmg/ddt118

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© The Author 2013. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permission@oup.com

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Figure 8. — Sac1 is sequestered into DVAP-P58S-mediated aggregates. (A) Eye imaginal discs and (B) brains stained for both DVAP and Flag in ey,DVAP-P58S/Flag-Sac1 and elav;DVAP-P58S/Flag-Sac1 larvae. Bar = 10 μm. (C) Graphical summary of the data. The left panel shows a chemical equilibrium between two reactions: one in which Sac1 interacts with DVAP to catalyse the conversion of PtdIns4P into PtdIns and another in which PI4K converts PtdIns into PtdIns4P. The right panel shows that depleting DVAP (i) or Sac1 (ii) or the aggregation of Sac1 and DVAP into DVAP-P58S-induced aggregates (iii) inhibits Sac1-mediated reaction leading to an increase in PtdIns4P levels.