Table 1.

Compounds Tested for Treatment of Diffuse Pontine Glioma

Primary Trials

tipifarnib (PBTC-014)

capecitabine RDT (PBTC-021)

vandetanib (SJBG07)

Recurrence Trials

06-benzylguanine and temozolomide (PBTC-015)

bevacizumab and irinotecan (PBTC-022)

In Design

bevacizumab, MGMT-directed temozolomide, and EGFR-directed erlotinib

Abbreviations: EGFR = epidermal growth factor receptor; MGMT = methylguanine-DNAmethyltransferase; PBTC = Pediatric Brain Tumor Consortium; RDT = rapidly disintegrating tablets; SJBG = St. Jude’s Brainstem Glioma.