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. Author manuscript; available in PMC: 2013 Jun 6.
Published in final edited form as: Physiol Rev. 2011 Jul;91(3):1023–1070. doi: 10.1152/physrev.00024.2010

FIGURE 2.

FIGURE 2

Pathways of AKT influencing the mTOR protein complexes. Schematic diagram representing the regulatory functions of the mTORC1 and mTORC2 complexes in relation to AKT signaling and cellular outcomes. Induction of AKT activity by extracellular signals results in the activation of mTORC1. mTORC2 activity positively regulates AKT activity. Green arrows represent positive regulation. Green arrows leading to phosphorylation represent activation via phosphorylation. Red arrows represent negative regulation. Red arrows leading to phosphorylation represent repression via phosphorylation.