Table 4.
Examples of microRNAs altered in myocardial diseases
| MicroRNAs Altered in Heart Diseases: (315) | Function | MicroRNAs Altered in Heart Diseases:(315) | Function |
|---|---|---|---|
| Let7b | Developmental timing (343) | miR100 | Stem cell differentiation (623), β-adrenergic signaling (609) |
| Let7c | Developmental timing (377) | miR101 | Epigenetic regulation (77, 653) |
| Let7e | Developmental timing (660) | miR103 | Mesenchymal stem cell signaling (425) |
| mir1 | Anti-hypertrophic (508) | miR106a | Cell cycle arrest and senescence (255, 405) |
| miR10a | Smooth muscle cell differentiation (642) | miR125b | Inhibitor of endothelin-1 (537) |
| miR15b | Pro-apoptotic, reduces cellular ATP (506) | miR126 | Angiogenesis (55, 196, 341, 505) |
| miR17-5p | Both anti-and pro-proliferative (452, 674) | miR140 | Reduced AKT and ERK activation (angiogenesis) (322) |
| miR19a, b | Target PTEN, anti-aging (255, 538) | miR145 | Vascular smooth muscle cell differentiation (55, 193) |
| miR20a, b | Pro-proliferative, anti-aging (255, 510) | miR181a | p27 repression (121) |
| miR23a, b | Early hypertrophic growth, regulate metabolism (72, 421, 658) | miR195 | Hypertrophic signaling (72, 649) |
| miR24 | Cell cycle arrest (394) | miR199a | Cardiomyocyte size maintenance (600) |
| miR26b | Cell proliferation (504) | miR214 | Cell survival (677) |
| miR27a, b | Pro-apoptotic, pro-differentiation (360, 689) | miR222 | Neovascularization (148, 374, 375, 540, 645) |
| miR30 | Myocardial matrix remodeling (170) | miR320 | Neovascularization (552, 660) |
| miR93 | Target VEGF (427) |