Figure 2.

Schematic diagram of glycan capture and release on solid-phase via dynamic covalent chemistry. Glycans are catalyzed by addition of aniline to formation of Schiff-based intermediate and further reacted to hydrazide or amine. The hydra-zone bond is stable at pH 7 or mild base condition, but can be easily hydrolyzed in acid condition e.g., 10% formic acid solution. Reprinted with permission from [28].