Table 3.
Differentially Expressed Kinase Genes (P < .01) in Astrocytoma Cells Following IGFBP2 Stimulation for 1 h and in High-Grade Astrocytomas
| Gene Name | GenBank ID | Average Fold Changea | P Valueb |
|---|---|---|---|
| Astrocytoma cells + IGFBP2 | |||
| DNA-PKcs (increased) | U47077 | 1.2 | <.01 |
| PTK9 (decreased) | U02680 | 0.4 | <.01 |
| High-grade astrocytomas | |||
| DNA-PKcs (increased) | U47077 | 2.37 | .0008 |
| PTK9 (no change) | U02680 | NCc | NSc |
Abbreviations: DNA-PKcs, DNA-dependent protein kinase catalytic subunit; PTK9, protein tyrosine kinase 9.
a
Data presented in log base 2.
b
Significance in differential gene expression between experimental classes (test and controls) and tumor classes was determined using permutational t test statistics.
c
NC, no change; NS, not significant.