TABLE 3. Final Multivariate Cox Proportional Hazards Models for Predicting Mortality, Death or Graft Loss Due to HCV, and Significant Fibrosis.
Predictor | HR | 95% CI | P Value |
---|---|---|---|
Mortality | |||
HW ethnicity | 1.06 | 0.71-1.60 | 0.77 |
Age (per 10 years) | 1.43 | 1.09-1.87 | 0.01 |
Donor age (per 10 years) |
1.25 | 1.10-1.87 | <0.001 |
Treated acute rejection | 1.47 | 1.01-2.29 | 0.048 |
Death or Graft Loss Due to HCV | |||
HW ethnicity | 1.04 | 0.53-2.05 | 0.91 |
Female sex | 2.37 | 1.21-4.64 | 0.01 |
Donor age (per 10 years) |
1.51 | 1.19-1.91 | 0.001 |
CIT (per hour) | 1.12 | 1.01-1.23 | 0.03 |
Significant Fibrosis | |||
HW ethnicity | 2.42 | 1.01-5.78 | 0.046 |
MHI (per $10,000) | 1.11 | 1.03-1.19 | 0.01 |
Ethnicity-MHI | 0.82 | 0.68-0.98 | 0.03 |
interaction | |||
Donor age (per 10 years) |
1.13 | 1.02-1.25 | 0.02 |
CIT (per hour) | 1.06 | 1.01-1.11 | 0.03 |
NOTE: The variables evaluated in the univariate and multivariate models included ethnicity, age at transplantation, sex, MHI, highest level of education, insurance status, BMI, diabetes, hypertension, hyperlipidemia, MELD score, donor type, HCC, donor age, CIT, cyclosporine use, post-LT HCV treatment (as a time-varying covariate), CMV treatment, treated acute rejection, and interaction terms (between ethnicity and MHI, highest level of education, insurance status, and center). All multivariate models were controlled for the center.