Table 1. Associations between the use of deodorant by the mother at 8m and by the partner during pregnancy and ABCC11 (rs17822931).
|
(a) Additive and recessive models | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Additive (copies of A allele) |
Recessive (AA genotype) |
|||||||||||
| Ethnicity of parent | N | B | 95% Confidence interval (CI) | P | Dev P | B | 95% CI | P | Dev P | |||
| Maternal genotype | ||||||||||||
| Use by mother 8m | Non-white | 136 | −1.52 | −2.12 | −0.92 | 1.5 × 10−6 | 0.8746 | −2.64 | −4.02 | −1.26 | 0.0002 | 0.0021 |
| White | 6,492 | −0.37 | −0.47 | −0.28 | 1.8 × 10−14 | 5.7 × 10−11 | −1.64 | −1.98 | −1.31 | 2.2 × 10−21 | 0.0007 | |
| Use by partner 12w | Non-white | 115 | −1.18 | −1.99 | −0.37 | 0.0046 | 0.1505 | −1.09 | −3.20 | 1.01 | 0.3051 | 0.0027 |
| White | 4,952 | 0.01 | −0.14 | 0.15 | 0.9040 | 0.1213 | −0.33 | −0.84 | 0.18 | 0.2026 | 0.3734 | |
| Child genotype | ||||||||||||
| Use by mother 8m | Non-white | 159 | −1.06 | −1.68 | −0.43 | 0.0011 | 0.2683 | −2.39 | −3.89 | −0.89 | 0.0019 | 0.1356 |
| White | 7,281 | −0.16 | −0.25 | −0.07 | 0.0004 | 0.8597 | −0.32 | −0.65 | 0.02 | 0.0640 | 0.0027 | |
| Use by partner 12w | Non-white | 119 | −1.43 | −2.20 | −0.67 | 0.0003 | 0.5595 | −2.85 | −4.69 | −1.02 | 0.0026 | 0.0389 |
| White | 5,563 | −0.16 | −0.30 | −0.02 | 0.0235 | 0.6224 | −0.41 | −0.93 | 0.12 | 0.1306 | 0.0791 | |
|
(b) Genotype model (effect for GG genotype constrained to be zero) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
GA genotype |
AA genotype |
Group | |||||||||
| Ethnicity of parent | N | B | 95% CI | P | B | 95% CI | P | P | |||
| Maternal genotype | |||||||||||
| Use by mother 8m | Non-white | 136 | −1.47 | −2.39 | −0.54 | 0.0021 | −3.10 | −4.46 | −1.73 | 1.6 × 10−5 | 1.0 × 10−5 |
| White | 6,492 | −0.19 | −0.30 | −0.08 | 0.0007 | −1.69 | −2.03 | −1.35 | 2.6 × 10−22 | 8.5 × 10−23 | |
| Use by partner 12w | Non-white | 115 | −1.79 | −2.94 | −0.63 | 0.0027 | −1.45 | −3.50 | 0.59 | 0.1610 | 0.0065 |
| White | 4,952 | 0.08 | −0.09 | 0.25 | 0.3734 | −0.31 | −0.82 | 0.20 | 0.2288 | 0.2988 | |
| Child genotype | |||||||||||
| Use by mother 8m | Non-white | 159 | −0.69 | −1.59 | 0.22 | 0.1356 | −2.59 | −4.10 | −1.07 | 0.0009 | 0.0027 |
| White | 7,281 | −0.16 | −0.26 | −0.06 | 0.0027 | −0.35 | −0.69 | −0.02 | 0.0397 | 0.0020 | |
| Use by partner 12w | Non-white | 119 | −1.19 | −2.32 | −0.06 | 0.0389 | −3.17 | −5.00 | −1.34 | 0.0009 | 0.0013 |
| White | 5,563 | −0.14 | −0.30 | 0.02 | 0.0791 | −0.44 | −0.97 | 0.09 | 0.1032 | 0.0682 | |
Abbreviations: m, months; w, weeks.Unadjusted linear regressions of deodorant usage on genotype. Effect sizes are the estimated change in frequency of deodorant use per week.
Dev P-value is a test of the deviation from the additive or recessive genetic model by comparison with the genotype model. The group test was a 2 d.f. test.