Table 3. Event Rates During the Successive Treatment Eras (Unadjusted).

	Era 1 1993-1998 (n=793)	Era 2 1999-2004 (n=879)	Era 3* 2005-2010 (n=835)	P value†	P trend‡
All-cause mortality
1 yr	20.6%	15.3%	17.8%	0.042	0.114
2 yr	27.9%	23.8%	25.5%	0.121	0.109
3 yr	36.4%	29.4%	31.5%	0.022	0.029
Sudden death
1 yr	6.9%	3.1%	2.0%	<0.001	<0.001
2 yr	8.1%	5.1%	4.7%	0.002	0.001
3 yr	10.1%	6.4%	4.6%	0.001	<0.001
Progressive HF death
1 yr	7.1%	7.0%	12.6%	0.002	0.002
2 yr	9.6%	9.4%	16.9%	0.004	0.006
3 yr	11.6%	11.3%	19.9%	0.004	0.007
Urgent transplant or VAD
1 yr	13.9%	14.0%	19.9%	0.002	0.002
2 yr	16.7%	16.5%	23.9%	0.002	0.003
3 yr	18.9%	18.5%	33.4%	<0.001	0.001
Urgent transplant
1 yr	13.9%	14.0%	18.7%	0.020	0.014
2 yr	16.7%	16.5%	23.7%	0.002	0.003
3 yr	18.9%	18.5%	33.4%	<0.001	0.001
VAD
1 yr	0%	0%	1.4%	<0.001	0.038
2 yr	0%	0%	0.2%	0.291	0.498
3 yr	0%	0%	0%	N/A	N/A
Non-urgent transplant
1 yr	11.2%	6.7%	8.1%	0.015	0.039
2 yr	16.7%	11.7%	14.1%	0.029	0.053
3 yr	19.4%	14.8%	15.9%	0.065	0.097
Mortality, urgent transplant or VAD
1 yr	31.6%	27.2%	34.2%	0.018	0.311
2 yr	40.0%	36.4%	45.3%	0.059	0.426
3 yr	48.5%	42.5%	53.4%	0.014	0.669

^†P values reflect the log rank (Mantel-Cox) test.

^*2005-2009 and 2005-2008 for 2 and 3 year analyses, respectively.

^‡P value for trend from the Cochran-Armitage test.