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Results of assays testing transcriptional regulations of mutant MCPH1s containing mutations at human-specific sites. (A-C) The results of the E2F4B assay testing the changes of enhancing effect. (D-E) The results of the p14ARF assay testing the repressing effect. All histograms represent the mean ± SD of at least nine data points including both biological and technical replicates (* P <0.05,** P <0.01, *** P <0.001, n.s, not significant).
