. 2013 Jun 6;9(6):e1003500. doi: 10.1371/journal.pgen.1003500

Table 1. Seven SNPs show sex difference.

				Discovery			Follow-up			Joint
				MEN	WOMEN	Sex-Diff	MEN	WOMEN	Sex-Diff	MEN	WOMEN	Sex-Diff	MEN	WOMEN
SNP	Trait^a	Sex^a	Gene^b	P	P	P	P^c	P^c	P^c	P	P	P	N	N
rs6717858	WHRadjBMI	W	GRB14/COBLL1	0.309	2.78E-15	6.49E-07	0.965	3.64E-16	1.08E-11	0.613	1.99E-29	6.18E-16	76,594	98,321
rs2820443	WHRadjBMI	W	LYPLAL1/SLC30A10	0.191	3.69E-18	1.25E-07	0.532	9.15E-21	2.60E-10	0.374	4.62E-37	6.95E-16	76,625	98,352
rs1358980	WHRadjBMI	W	VEGFA	0.110	1.11E-13	3.02E-05	0.112	1.38E-19	4.53E-08	0.048	2.41E-31	2.46E-11	75,703	97,269
rs11743303	WCadjBMI	W	MAP3K1	0.974	2.27E-06	6.24E-04	0.172	7.15E-07	5.35E-05	0.570	2.69E-11	8.41E-07	85,136^d	107,403^d
rs2371767	WHRadjBMI	W	ADAMTS9	0.196	1.63E-08	1.85E-03	6.08E-03	8.55E-17	2.14E-04	8.34E-03	7.07E-23	1.91E-06	72,649	95,325
rs10478424	WHRadjBMI	W	HSD17B4	0.399	1.02E-05	9.84E-03	0.864	3.81E-05	1.67E-03	0.761	3.45E-09	2.66E-04	43,852^e	73,066^e
rs4684854	WHRadjBMI	W	PPARG	0.955	2.36E-08	6.46E-05	0.132	1.48E-07	4.22E-03	0.411	4.17E-14	4.04E-06	74,652	96,472

Trait and sex for which the SNP was selected;

Gene labels state the nearest gene or the gene as published previously; details on all genes near the association signal can be found in the Figure S2;

One-sided P-Values.

larger sample size due to one additional study that did not have hip circumference, and therefore could not contribute to WHRadjBMI.

smaller sample size as this SNP was not on Metabochip.

Shown are the seven SNPs with significant (at 5% false discovery rate) sex difference in the follow-up data. These seven SNPs exhibit genome-wide significant association in women (joint discovery and follow-up P_women<5×10−8) and only two of these show nominally significant association in men (joint P_men<0.05). The three loci MAP3K1, HSD17B4, and PPARG are shown here for the first time for their anthropometric trait association as well as for sex-difference.