Table 3. Strongest associated, genotyped single nucleotide polymorphisms (SNPs) for corneal astigmatism.

SNP	CHR	bp	Allele	Raine (n=1013)			TEST/BATS (n=1771)		P value	Meta-analysis
				Effect	SEM	P value	Effect	SEM		Beta	SEM	P value
rs1151008	12	31,988,627	G	−0.138	0.046	3.07×10−3	−0.15	0.038	7.50×10−5	−0.144	0.03	1.37×10−6
rs1164064	3	1.11E+08	A	0.212	0.043	9.91×10−7	0.065	0.037	7.50×10−2	0.134	0.028	1.86×10−6
rs11841001	13	75,147,104	A	0.185	0.072	1.10×10−2	0.195	0.057	6.30×10−4	0.208	0.045	4.31×10−6
rs7651778	3	1.58E+08	C	0.096	0.043	2.64×10−2	0.139	0.036	9.30×10−5	0.126	0.028	4.76×10−6
rs11859036	16	78,863,052	A	0.145	0.043	8.74×10−4	0.107	0.037	3.60×10−3	0.128	0.029	7.03×10−6
rs438465	6	1.7E+08	C	−0.211	0.058	2.70×10−4	−0.143	0.051	5.50×10−3	−0.173	0.039	7.22×10−6
rs979976	2	1.37E+08	A	0.163	0.047	4.81×10−4	0.102	0.038	7.20×10−3	0.134	0.03	7.52×10−6
rs4805442	19	34,780,233	A	−0.192	0.06	1.48×10−3	−0.141	0.05	4.40×10−3	−0.168	0.038	1.18×10−5
rs10079889	5	33,011,247	A	0.165	0.052	1.50×10−3	0.124	0.043	4.30×10−3	0.145	0.033	1.38×10−5
rs2116538	2	1.37E+08	A	−0.162	0.052	1.92×10−3	−0.135	0.044	2.10×10−3	−0.146	0.034	1.63×10−5

Top ranking SNPs at loci identified through genome-wide meta-analysis following adjustment for age and sex as well as the results from individual cohorts.